Neural stem cells secrete factors facilitating brain regeneration upon constitutive Raf-Erk activation
نویسندگان
چکیده
منابع مشابه
Neural stem cells secrete factors facilitating brain regeneration upon constitutive Raf-Erk activation
The intracellular Raf-Erk signaling pathway is activated during neural stem cell (NSC) proliferation, and neuronal and astrocytic differentiation. A key question is how this signal can evoke multiple and even opposing NSC behaviors. We show here, using a constitutively active Raf (ca-Raf), that Raf-Erk activation in NSCs induces neuronal differentiation in a cell-autonomous manner. By contrast,...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep32025